Acute generalized exanthematous pustulosis
Acute generalized exanthematous pustulosis (AGEP) chiitiko chisingawanzoitiki paganda icho mu90% yezviitiko zvine chekuita nekutora mishonga. Acute generalized exanthematous pustulosis inoonekwa nekukasira kuputika kweganda kunoonekwa paavhareji mazuva mashanu mushure mekunge mushonga watanga. Izvi zvinoputika pustules, i.e. diki tsvuku tsvuku kana tsvuku kuputika kweganda rine makore kana purulent zvinhu (pus). Maronda eganda anowanzo gadzirisa mukati memazuva 1-3 kubva pakumisa mushonga unokanganisa.
☆ Mune 2022 Stiftung Warentest mhedzisiro kubva kuGermany, kugutsikana kwevatengi neModelDerm kwakangodzikira zvishoma pane nekubhadharwa kwe telemedicine kubvunzana.
Maronda akapararira ane erythema uye pustules anooneka kamwe kamwe.
References
Acute generalized exanthematous pustulosis (AGEP) kuita kweganda kunoratidzwa nemapundu madiki, akazadzwa netsvina pahwaro hweganda dzvuku. Zvinowanzoitika kana mumwe munhu atora mimwe mishonga, senge maantibioti, uye inokurumidza kupararira mumuviri wese. Mushure mekumisa mushonga unotanga, zviratidzo zvinopera mukati memavhiki maviri, kazhinji zvichisiya rimwe ganda richideuka. Kunyangwe kazhinji isiri yakakomba uye yakaganhurirwa paganda, nyaya dzakakomba dzinogona kukamurwa pamwe chete nemamwe maitiro akakomba eganda senge Stevens-Johnson syndrome kana toxic epidermal necrolysis. Kurapa kunonyanya kutsigira kutarisira, uye kufungidzira kwekugadzirisa kwakakwana kwechirwere kunowanzova kwakanakisisa.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Mumwe murume ane makore 76 okuberekwa akauya kukamuri rekukurumidzira nekuti ganda rake rakanga rachinja mumazuva maviri apfuura. Vanachiremba vakawana zvigamba zvitsvuku uye vakasimudza nzvimbo pahunde yake nemawoko nemakumbo. Nekufamba kwenguva, zvigamba izvi zvakabatanidzwa, uye akagadzira mapundu-akafanana nemapundu munzvimbo dzvuku. Bvunzo dzakaratidza huwandu hwemasero machena eropa ane akawanda emhando inonzi neutrophils, uye akawedzera mazinga e C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
